{"id":8196,"date":"2020-06-19T13:38:01","date_gmt":"2020-06-19T17:38:01","guid":{"rendered":"http:\/\/localhost:10028\/uncategorized\/bladder-medication-can-cause-blindness\/"},"modified":"2020-06-19T13:38:01","modified_gmt":"2020-06-19T17:38:01","slug":"mesane-ilaci-korluge-neden-olabilir","status":"publish","type":"post","link":"https:\/\/napolilaw.lemonadestand.org\/tr\/article\/mesane-ilaci-korluge-neden-olabilir\/","title":{"rendered":"Mesane \u0130lac\u0131 K\u00f6rl\u00fc\u011fe Neden Olabilir"},"content":{"rendered":"

Yetim ila\u00e7 g\u00f6rme yetisini etkiliyor <\/strong><\/h2>\n

Onlarca y\u0131ld\u0131r yayg\u0131n olarak re\u00e7ete edilen Elmiron mesane ilac\u0131<\/a> yak\u0131n zamanda retina i\u00e7in toksik oldu\u011fu bulunmu\u015ftur (hasar).<\/p>\n

Amerikan Oftalmoloji Akademisi taraf\u0131ndan 2018'de yay\u0131nlanan bir makale, interstisyel sistit i\u00e7in kronik olarak Elmiron'a (pentosan polis\u00fclfat sodyum) maruz kald\u0131ktan sonra pigmenter mak\u00fclopati ya\u015fayan alt\u0131 hastay\u0131 tan\u0131mlad\u0131.<\/p>\n

Ertesi y\u0131l, bir g\u00fcncelleme, on ba\u015fka IC hastas\u0131na ayn\u0131 ko\u015fulla te\u015fhis edildi\u011fini kaydetti.<\/p>\n

Yakla\u015fan davalar<\/strong><\/h2>\n

Elmiron laboratuvar\u0131na yap\u0131lan \u015fikayetler, esas olarak a\u011fr\u0131l\u0131 mesane sendromunu tedavi etmek i\u00e7in geli\u015ftirilen bu yetim ilac\u0131n uzun s\u00fcreli kullan\u0131m\u0131n\u0131n pigmenter mak\u00fclopati ad\u0131 verilen nadir bir g\u00f6z rahats\u0131zl\u0131\u011f\u0131na neden olabilece\u011fini iddia ediyor.<\/p>\n

Retinan\u0131n merkezi k\u0131sm\u0131n\u0131 (makula) etkileyen bu tip makula dejenerasyonu k\u00f6rl\u00fc\u011fe yol a\u00e7abilir.<\/p>\n

May\u0131s 2020'de J&J yan kurulu\u015fu Janssen Pharmaceuticals aleyhine, Elmiron alan hastalar\u0131n vizyonunu izlemek i\u00e7in bir fon olu\u015fturmak \u00fczere s\u0131n\u0131f sertifikas\u0131 almak isteyen bir dava a\u00e7\u0131ld\u0131.<\/p>\n

Kal\u0131c\u0131 \u015fikayetlerle IC hastalar\u0131 taraf\u0131ndan ba\u015fka birka\u00e7 dava da a\u00e7\u0131lm\u0131\u015ft\u0131r. g\u00f6rme kayb\u0131<\/a> bu mesane ilac\u0131n\u0131n neden oldu\u011fu.<\/p>\n

\u0130ki y\u0131ld\u0131r piyasada<\/strong><\/h2>\n

1996 y\u0131l\u0131nda FDA taraf\u0131ndan onaylanan Elmiron, ilk olarak, 2001 y\u0131l\u0131nda $10.5 milyar hisse senedi i\u015flemiyle Johnson & Johnson ile birle\u015fen Alza Corporation'a aitti.<\/p>\n

O zamandan beri Janssen Pharmaceuticals, Elmiron'u J&J \u015femsiyesi alt\u0131nda pazarlamaktad\u0131r.<\/p>\n

Bununla birlikte, bu laboratuvar\u0131n bu ila\u00e7la ili\u015fkili herhangi bir retinopati veya mak\u00fclopati uyar\u0131s\u0131 vermedi\u011fi ve hastalara d\u00fczenli g\u00f6z muayeneleri yoluyla g\u00f6rmelerini izlemelerini \u00f6nermedi\u011fi iddialar\u0131 vard\u0131r.<\/p>\n

\u0130nterstisyel sistit tedavisi i\u00e7in FDA taraf\u0131ndan onaylanm\u0131\u015f olmas\u0131na ra\u011fmen, etki mekanizmas\u0131 hala bilinmemektedir.<\/p>\n

Hassas mesane astar\u0131 i\u00e7in bir tampon g\u00f6revi g\u00f6rd\u00fc\u011f\u00fcne inan\u0131lan - daha az s\u0131zd\u0131ran ve dolay\u0131s\u0131yla daha az iltihapl\u0131 ve a\u011fr\u0131l\u0131 hale getiren - bu ila\u00e7, hassas mukoza zarlar\u0131n\u0131 idrardaki tahri\u015f edici maddelerden koruyarak h\u00fccre ge\u00e7irgenli\u011fini kontrol edebilir.<\/p>\n

G\u00fcnde \u00fc\u00e7 kez bir kaps\u00fcl olarak al\u0131nan Elmiron (pentosan polis\u00fclfat sodyum), pentosan zay\u0131f antikoag\u00fclan etkileri olan insan yap\u0131m\u0131 bir ila\u00e7 oldu\u011fundan kan suland\u0131r\u0131c\u0131 heparine benzer.<\/p>\n

Etkili bir fibrinolitiktir, mesane astar\u0131n\u0131 g\u00fc\u00e7lendirir, daha az iltihaplanma ve a\u011fr\u0131 i\u00e7in s\u0131z\u0131nt\u0131lar\u0131 t\u0131kar.<\/p>\n

B\u00fcy\u00fck veri taban\u0131 \u00e7al\u0131\u015fmas\u0131<\/strong><\/h2>\n

Ekim 2019'da Kaiser Permanente'deki ilgili \u00fc\u00e7 g\u00f6z doktoru taraf\u0131ndan y\u00fcr\u00fct\u00fclen bir ara\u015ft\u0131rma, uzun s\u00fcreli Elmiron kullan\u0131m\u0131n\u0131n ger\u00e7ekten de retina hasar\u0131yla ba\u011flant\u0131l\u0131 oldu\u011funu g\u00f6sterdi.<\/p>\n

Kaiser'in 4,3 milyon ismin yer ald\u0131\u011f\u0131 veritaban\u0131n\u0131 tarayarak, on be\u015f y\u0131ll\u0131k tedavi boyunca her biri ortalama 5000 hap alm\u0131\u015f 140 IC hastas\u0131 buldular ve bunlardan 91'i test i\u00e7in gelmeyi kabul etti.<\/p>\n

Ayr\u0131nt\u0131l\u0131 retina g\u00f6r\u00fcnt\u00fclemesinden sonra normal, olas\u0131 anormallik ve kesin anormallik olmak \u00fczere \u00fc\u00e7 kategoriye ayr\u0131ld\u0131lar.<\/p>\n

Bunlardan 22'si, al\u0131nan ilac\u0131n miktar\u0131na paralel olarak y\u00fckselen bu oran ile a\u00e7\u0131k ila\u00e7 toksisitesi belirtileri g\u00f6sterdi: 500 ila 1000 gram alan hastalarda 11%'den 1500 gram veya daha fazla alan hastalarda 42%'ye y\u00fckseldi.<\/p>\n

Mevcut \u00f6neri, Elmiron'u hi\u00e7bir toksisite belirtisi g\u00f6stermeden alan hastalar\u0131n y\u0131lda en az bir kez retina hasar\u0131 a\u00e7\u0131s\u0131ndan taranmas\u0131 ve g\u00f6rme g\u00fc\u00e7l\u00fc\u011f\u00fc \u00e7eken herkesin bu ilac\u0131 b\u0131rakma olas\u0131l\u0131\u011f\u0131n\u0131 doktorlar\u0131yla g\u00f6r\u00fc\u015fmesi gerekti\u011fi y\u00f6n\u00fcndedir.<\/p>\n

Endikasyon d\u0131\u015f\u0131 kullan\u0131mlar<\/strong><\/h2>\n

A\u011fr\u0131l\u0131 mesane sendromunun tedavisine ek olarak, Elmiron osteoartrit i\u00e7in de re\u00e7ete edilir.<\/p>\n

Bu if\u015fadan \u00f6nce, Avustralya'da yap\u0131lmakta olan ara\u015ft\u0131rmalar, enjekte edilebilir bir Elmiron formu yoluyla enflamasyonun \u00fcstesinden gelmek i\u00e7in pentosan polis\u00fclfat sodyumun (PPS) yeniden amaca y\u00f6nelik olarak kullan\u0131lmas\u0131na odaklanm\u0131\u015ft\u0131.<\/p>\n

\u0130ltihab\u0131 \u00f6nleyici etkileri oldu\u011fu ve kemik ili\u011fi lezyonlar\u0131n\u0131 kontrol alt\u0131na alarak a\u011fr\u0131y\u0131 \u00f6nledi\u011fi \u00f6ne s\u00fcr\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n

Diz yaralanmalar\u0131na \u00f6zellikle e\u011filimli olan Amerikan ve Avustralya futbol ligi oyuncular\u0131na, endikasyon d\u0131\u015f\u0131 bir denemede alt\u0131 hafta boyunca haftada iki kez PPS enjekte edildi ve diz a\u011fr\u0131s\u0131 seviyelerinde \u00f6nemli azalmalar bildirildi.<\/p>\n

Elmiron ile tedavi i\u00e7in d\u00fc\u015f\u00fcn\u00fclen di\u011fer durumlar aras\u0131nda derin ven trombozu ve Ross Nehri ate\u015fi (viral osteoartrit) ve muko-poli-sakkaridoz (MPS) gibi daha nadir hastal\u0131klar yer al\u0131r.<\/p>\n

D\u00fcnyan\u0131n ba\u015fka yerlerinde, pentosan polis\u00fclfat sodyumun prostat iltihaplanmas\u0131n\u0131 ve hatta psikotik bozukluklar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131p kullan\u0131lamayaca\u011f\u0131n\u0131 ara\u015ft\u0131ran ba\u015fka denemeler var.<\/p>\n

Di\u011fer yan etkiler<\/strong><\/h2>\n

\u00c7ok yak\u0131n zamana kadar, yan etkiler<\/a> Elmiron nispeten hafif olarak g\u00f6r\u00fcld\u00fc: mide a\u011fr\u0131s\u0131, ishal, mide bulant\u0131s\u0131 ve kanl\u0131 d\u0131\u015fk\u0131; depresyon, ba\u015f d\u00f6nmesi ve ba\u015f a\u011fr\u0131lar\u0131; morarma, k\u0131zar\u0131kl\u0131k ve sa\u00e7 d\u00f6k\u00fclmesi; kilo al\u0131m\u0131na ve \u015fi\u015fkinli\u011fe neden olan s\u0131v\u0131 birikiminin yan\u0131 s\u0131ra.<\/p>\n

Bununla birlikte, ilac\u0131n yararlar\u0131 bu rahats\u0131zl\u0131klardan daha a\u011f\u0131r basma e\u011filimindeydi.<\/p>\n

H\u0131zl\u0131 kendi kendini onarmak i\u00e7in tasarlanan mesane, ila\u00e7 korumal\u0131 \u00f6zel h\u00fccreleri hasar g\u00f6rm\u00fc\u015f astar dokusunu geri y\u00fckledi\u011finden, idrardaki sert at\u0131k maddelere kar\u015f\u0131 do\u011fal bariyerini h\u0131zla iyile\u015ftirebilir.<\/p>\n

Y\u00fcksek maliyetler<\/strong><\/h2>\n

Daha yayg\u0131n olarak kullan\u0131lan ila\u00e7lar\u0131n devasa pazarlar\u0131ndan yoksun olan Elmiron, d\u00fc\u015f\u00fck hacimleri y\u00fcksek fiyatlarla dengeliyor.<\/p>\n

Bir ayl\u0131k arz (90 kaps\u00fcl) i\u00e7in $1.300 dolar\u0131n \u00fczerindeki raf fiyat\u0131, SingleCare kuponuyla $900 civar\u0131na d\u00fc\u015f\u00fcyor.<\/p>\n

Ve hi\u00e7bir jenerik alternatif bulunmad\u0131\u011f\u0131ndan, bu tercih edilmeyen Kademe IV \u00f6zel ila\u00e7, muhtemelen t\u0131bbi yard\u0131m programlar\u0131ndan \u00f6n izin almay\u0131 gerektirir ve hastalar maliyetin 60%'sine kadar ortak \u00f6deme yapmak zorundad\u0131r.<\/p>\n

T\u0131bbi olmayan \u00e7areler\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><\/h2>\n

K\u00f6rl\u00fck riskine girmek istemeyen mesane iltihab\u0131 hastalar\u0131na art\u0131k durumlar\u0131n\u0131 y\u00f6netmek i\u00e7in \u00e7ok az alternatif kal\u0131yor.<\/p>\n

Bununla birlikte, ara\u015ft\u0131rmalar, \u00f6zellikle yapay tatland\u0131r\u0131c\u0131lar ile en rahats\u0131z edici olanlar aras\u0131nda kahve, \u00e7ay, soda, alkol ve narenciye sular\u0131 ile diyetin IC parlamalar\u0131n\u0131 tetikleyebilece\u011fini g\u00f6stermektedir.<\/p>\n

Ac\u0131 biber ve baharatl\u0131 yiyecekler bariz tehlikelerdir.<\/p>\n

Bu t\u00fcr mesane tahri\u015f edici maddelerin ortadan kald\u0131r\u0131lmas\u0131 ve potasyum sitrat veya kabartma tozu ile alkalile\u015ftirmenin art\u0131r\u0131lmas\u0131, \u00f6zellikle d\u00fczenli su al\u0131m\u0131 idrar\u0131n iyi seyreltilmesini sa\u011flad\u0131\u011f\u0131nda, bir\u00e7ok IC hastas\u0131na yard\u0131mc\u0131 olabilir.<\/p>\n

\u0130leriye bakmak<\/strong><\/h2>\n

Alternatif bir ilac\u0131 olmayan mesane hastalar\u0131 i\u00e7in, sonu\u00e7 olarak, k\u00fc\u00e7\u00fck ya\u015fam tarz\u0131 de\u011fi\u015fiklikleri, en az\u0131ndan yeni bir ila\u00e7 piyasaya s\u00fcr\u00fclene kadar ya\u015fam kalitelerini art\u0131rabilir.<\/p>\n

Ancak Janssen Pharmaceuticals i\u00e7in, bu trajik yan etkinin finansal sonu\u00e7lar\u0131 \u00e7ok yak\u0131nda ortaya \u00e7\u0131kabilir.<\/p>","protected":false},"excerpt":{"rendered":"

Yetim ila\u00e7 g\u00f6rme yetisini etkiliyor On y\u0131llard\u0131r yayg\u0131n olarak re\u00e7ete edilen Elmiron mesane ilac\u0131n\u0131n yak\u0131n zamanda retina i\u00e7in toksik oldu\u011fu (hasar) bulundu. taraf\u0131ndan yay\u0131nlanan bir makale\u2026<\/p>","protected":false},"author":3,"featured_media":8197,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[776],"tags":[875,877,914,917,918,926,971,1013,1014],"class_list":["post-8196","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pharmaceutical-litigation","tag-bad-drugs","tag-drug-side-effects","tag-pharmaceutical-litigation-attorney","tag-pharmaceutical-lawsuit","tag-pharmaceutical-lawyers","tag-pharmaceutical-law","tag-health-and-safety","tag-elmiron","tag-elmiron-eye-disease-lawyers"],"acf":[],"page_builder_type":"gutenberg","gutenberg_data":[],"_links":{"self":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts\/8196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/comments?post=8196"}],"version-history":[{"count":0,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts\/8196\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/media\/8197"}],"wp:attachment":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/media?parent=8196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/categories?post=8196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/tags?post=8196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}