{"id":15586,"date":"2023-05-26T08:30:00","date_gmt":"2023-05-26T12:30:00","guid":{"rendered":"https:\/\/www.napolilaw.com\/?p=15586"},"modified":"2023-05-19T12:59:58","modified_gmt":"2023-05-19T16:59:58","slug":"can-doktorlar-spot-parkinson-once-hasta-semptomlari","status":"publish","type":"post","link":"https:\/\/napolilaw.lemonadestand.org\/tr\/article\/can-doktorlar-spot-parkinson-once-hasta-semptomlari\/","title":{"rendered":"Doktorlar Hastalar Semptom G\u00f6stermeden \u00d6nce Parkinson Hastal\u0131\u011f\u0131n\u0131 Tespit Edebilir mi?"},"content":{"rendered":"<p>Erken tan\u0131ya ek olarak, <a href=\"https:\/\/www.thelancet.com\/journals\/laneur\/article\/PIIS1474-4422(23)00109-6\/fulltext#%20\" target=\"_blank\" rel=\"noopener\">yeni teknik<\/a> doktorlar\u0131n erken evre Parkinson Hastal\u0131\u011f\u0131 (PD) i\u00e7in daha iyi tedavi planlar\u0131 olu\u015fturmas\u0131n\u0131 sa\u011flayabilir. Alfa-sin\u00fcklein tohum amplifikasyon testi (SAA), beyinde Parkinson hastal\u0131\u011f\u0131na ba\u011fl\u0131 anormal protein birikintilerini arar. Bu proteinler semptomlar geli\u015fmeden \u00e7ok \u00f6nce birikmeye ba\u015flad\u0131\u011f\u0131ndan, bu analiz \u00e7ok daha erken a\u015famalarda tespit anlam\u0131na gelebilir. <a href=\"https:\/\/www.aboutlawsuits.com\/parkinsons-disease-diagnosis-study\/?utm_medium=email&amp;_hsmi=257041168&amp;_hsenc=p2ANqtz-_bklT3QJsSlSR3jHMu9C5GpcrZI-HXgpLrN2UjiqFWVzUeXKjhi5M0TL9dSe7uYAeOG7DL0DJ3Itu2M0VdSKWVdP0Fvg&amp;utm_content=257041168&amp;utm_source=hs_email\" target=\"_blank\" rel=\"noopener\">SAA y\u00fczde 95 do\u011fruluk oran\u0131na sahipti<\/a>. Baz\u0131 Parkinson hastal\u0131\u011f\u0131 t\u00fcrleri i\u00e7in, <a href=\"https:\/\/www.aboutlawsuits.com\/parkinsons-disease-diagnosis-study\/?utm_medium=email&amp;_hsmi=257041168&amp;_hsenc=p2ANqtz-_bklT3QJsSlSR3jHMu9C5GpcrZI-HXgpLrN2UjiqFWVzUeXKjhi5M0TL9dSe7uYAeOG7DL0DJ3Itu2M0VdSKWVdP0Fvg&amp;utm_content=257041168&amp;utm_source=hs_email\" target=\"_blank\" rel=\"noopener\">do\u011fruluk oranlar\u0131 y\u00fczde 96&#039;y\u0131 a\u015ft\u0131<\/a>. Ara\u015ft\u0131rmac\u0131lar, &quot;Sonu\u00e7lar\u0131m\u0131z, tahlilin Parkinson hastal\u0131\u011f\u0131 olan ki\u015fileri y\u00fcksek hassasiyet ve \u00f6zg\u00fcll\u00fckle s\u0131n\u0131fland\u0131rd\u0131\u011f\u0131n\u0131, molek\u00fcler heterojenite hakk\u0131nda bilgi sa\u011flad\u0131\u011f\u0131n\u0131 ve te\u015fhisten \u00f6nce prodromal bireyleri tespit etti\u011fini g\u00f6steriyor&quot; dedi. &quot;Bu bulgular, hem Parkinson hastal\u0131\u011f\u0131 olan ki\u015filerin patolojik olarak tan\u0131mlanm\u0131\u015f alt gruplar\u0131n\u0131 belirlemek hem de biyobelirte\u00e7 tan\u0131ml\u0131 risk alt\u0131ndaki kohortlar\u0131 olu\u015fturmak i\u00e7in terap\u00f6tik geli\u015fimde a-sin\u00fcklein SAA&#039;n\u0131n \u00e7ok \u00f6nemli bir rol\u00fc oldu\u011funu g\u00f6steriyor.&quot;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Parkinson Hastal\u0131\u011f\u0131 Hakk\u0131nda<\/h2>\n\n\n\n<p>Normalde kronik, ciddi hastal\u0131klarda oldu\u011fu gibi, doktorlar \u00e7evresel ve genetik fakt\u00f6rlerin bir kombinasyonunun PH&#039;ye neden oldu\u011fundan \u015f\u00fcpheleniyorlar. Sinir h\u00fccreleri bozulduk\u00e7a, hastalar titreyen eller, kat\u0131la\u015fan kaslar ve ayaklar\u0131n kaymas\u0131 gibi motor beceri g\u00fc\u00e7l\u00fckleri ya\u015farlar. Daha sonra, \u00e7o\u011funlukla demans olmak \u00fczere zihinsel semptomlar ortaya \u00e7\u0131kar. 2000&#039;li y\u0131llar\u0131n ba\u015f\u0131ndan bu yana, PH \u00f6l\u00fcm oran\u0131 <a href=\"https:\/\/www.ajmc.com\/view\/large-study-finds-parkinson-disease-us-death-rate-soared-63-over-20-years\" target=\"_blank\" rel=\"noopener\">y\u00fczde 63 artt\u0131<\/a>. Bu \u00e7arp\u0131c\u0131 art\u0131\u015f, hastal\u0131\u011f\u0131n daha \u00e7ok \u00e7evresel bir sorun olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcr\u00fcyor. Ara\u015ft\u0131rmac\u0131lar, yukar\u0131da belirtilen \u00f6lmekte olan sinir h\u00fccrelerinin, beynin bir\u00e7ok n\u00f6rolojik ve motor beceri i\u015flevini kontrol eden bir alan\u0131 olan bazal ganglionlardaki dopamin arz\u0131n\u0131 etkiledi\u011fini d\u00fc\u015f\u00fcn\u00fcyor. \u015eu anda PD&#039;nin tedavisi yoktur. MAO-B inhibit\u00f6rleri ve dopamin agonistleri gibi mevcut birka\u00e7 ila\u00e7, en az\u0131ndan ge\u00e7ici olarak semptomlar\u0131 y\u00f6netir. Hastal\u0131k ilerledik\u00e7e, bu ila\u00e7lar daha az etkili hale gelir. Deneysel cerrahi, ila\u00e7lar etkisiz kalmaya ba\u015flad\u0131\u011f\u0131nda semptomlar\u0131 azaltabilir, ancak bir kez daha, bu cerrahi PH&#039;yi iyile\u015ftirmez; sadece hastalara biraz daha zaman verir. Genel olarak, PD&#039;ler <a href=\"https:\/\/www.nia.nih.gov\/health\/parkinsons-disease\" target=\"_blank\" rel=\"noopener\">en tan\u0131nabilir semptomlar<\/a> titreme, bradikinezi (kas hareketinin tamamen kayb\u0131), kat\u0131l\u0131k ve ayaklar\u0131n\u0131 s\u00fcr\u00fcyerek\/e\u011fimli y\u00fcr\u00fcmeyi i\u00e7erir. Otonomik disfonksiyon (dysautonomia), n\u00f6ropsikiyatrik problemler (ruh hali, bili\u015f, davran\u0131\u015f veya d\u00fc\u015f\u00fcnce de\u011fi\u015fiklikleri), duyusal (\u00f6zellikle de\u011fi\u015fen koku alma duyusu) ve uyku g\u00fc\u00e7l\u00fckleri dahil olmak \u00fczere motor olmayan semptomlar da mevcut olabilir. Demans, psikoz, ortostaz ve ciddi d\u00fc\u015fmeler gibi daha \u015fiddetli semptomlar daha sonra ortaya \u00e7\u0131kar. Egzersiz PD riskini azalt\u0131r. \u00d6n haz\u0131rl\u0131k <a href=\"https:\/\/www.nia.nih.gov\/health\/parkinsons-disease\" target=\"_blank\" rel=\"noopener\">\u00e7al\u0131\u015fmalar<\/a> ibuprofen ve benzeri ila\u00e7lar\u0131n bu hastal\u0131\u011f\u0131 da engelleyebilece\u011fini g\u00f6stermektedir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Parkinson Hastal\u0131\u011f\u0131 ve \u00c7evresel Toksinler<\/h2>\n\n\n\n<p>Baz\u0131 \u00e7evresel toksinler, di\u011ferlerinden daha fazla olumsuz sa\u011fl\u0131k etkisine sahiptir. Bu toksinlerden baz\u0131lar\u0131 \u015funlard\u0131r:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Pestisitler\/Herbisitler<\/strong>: \u00c7oklu <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/16802290\/\" target=\"_blank\" rel=\"noopener\">\u00e7al\u0131\u015fmalar<\/a> pestisitler ve herbisitlerdeki kimyasallar\u0131 Parkinson hastal\u0131\u011f\u0131 ile ili\u015fkilendirmi\u015ftir. Bu maddeler aras\u0131nda rotenon ve permetrin (sivrisinek \u00f6ld\u00fcr\u00fcc\u00fc giysilerde veya a\u011flarda yayg\u0131n olarak bulunan bile\u015fenler), DDT ve beta-hekzaklorosikloheksan gibi di\u011fer organoklorinler, <a href=\"https:\/\/napolilaw.lemonadestand.org\/tr\/uygulama-alanlari-2\/ulke-capinda-paraquat-parkinson-hastaligi-avukatlari\/\">parakuat<\/a> ve 2,4-diklorofenoksiasetik asit (2,4-D).<\/li>\n\n\n\n<li><strong>MPTP<\/strong>: 1980&#039;lerde Kaliforniya&#039;daki baz\u0131 damar i\u00e7i uyu\u015fturucu kullan\u0131c\u0131lar\u0131, MPTP ile kontamine olmu\u015f sentetik eroin kulland\u0131lar. G\u00fcnler i\u00e7inde PD semptomlar\u0131 geli\u015ftirdiler. 1-metil-4-fenil-1,2,3,6-tetrahidropiridin de baz\u0131 pestisitlerde bulunur.<\/li>\n\n\n\n<li><strong>Ajan Turuncu<\/strong>: Herbisit 2,4-D i\u00e7eren bu g\u00fc\u00e7l\u00fc yaprak d\u00f6k\u00fcc\u00fc, Vietnam Sava\u015f\u0131 s\u0131ras\u0131nda yayg\u0131n olarak kullan\u0131ld\u0131. Son zamanlarda, <a href=\"https:\/\/www.publichealth.va.gov\/exposures\/agentorange\/conditions\/parkinsonsdisease.asp#:~:text=Research%20on%20Parkinson&#039;s%20disease%20and%20herbicides&amp;text=As%20a%20result%2C%20VA%20recognized,health%20effects%20of%20Agent%20Orange.\" target=\"_blank\" rel=\"noopener\">ABD Gaziler \u0130\u015fleri Bakanl\u0131\u011f\u0131 Parkinson hastal\u0131\u011f\u0131n\u0131 ekledi<\/a> muhtemelen buna maruz kalmayla ili\u015fkili ko\u015fullar\u0131n bir listesine.<\/li>\n\n\n\n<li><strong>Manganez ve Di\u011fer Metaller<\/strong>: Kaynak\u00e7\u0131l\u0131k ve ilgili mesleklerde yayg\u0131n olan y\u00fcksek doz manganez maruziyeti, manganizm ad\u0131 verilen bir Parkinsonizm bi\u00e7imine neden olur. Kur\u015funa maruz kalma, daha y\u00fcksek bir Parkinson riski ile de ili\u015fkilendirilebilir.<\/li>\n\n\n\n<li><strong>\u00e7\u00f6z\u00fcc\u00fcler<\/strong>: Yayg\u0131n olarak kullan\u0131lan bir \u00e7\u00f6z\u00fcc\u00fc olan trikloretilen, metal ya\u011f giderme ve kuru temizlemede, ayr\u0131ca boya inceltici ve deterjanlarda kullan\u0131l\u0131r. Bir\u00e7ok <a href=\"https:\/\/www.urmc.rochester.edu\/news\/story\/common-dry-cleaning-chemical-linked-to-parkinsons-disease#:~:text=TCE%20and%20Parkinson&#039;s%20disease&amp;text=In%20animal%20studies%2C%20TCE%20causes,elevated%20risk%20of%20developing%20Parkinson&#039;s.\" target=\"_blank\" rel=\"noopener\">\u00e7al\u0131\u015fmalar<\/a> \u00e7\u00f6z\u00fcc\u00fclere uzun s\u00fcreli maruz kalma ile Parkinson geli\u015fimi aras\u0131nda bir ba\u011flant\u0131 oldu\u011funu g\u00f6stermektedir.<\/li>\n\n\n\n<li><strong>Organik Kirleticiler<\/strong>: PCB&#039;ler veya poliklorlu bifeniller, 1970&#039;lerde yasaklanana kadar \u00e7e\u015fitli end\u00fcstriyel i\u015flemlerde kullan\u0131ld\u0131. Ara\u015ft\u0131rmac\u0131lar, Parkinson hastalar\u0131n\u0131n beyinlerinde y\u00fcksek konsantrasyonlarda PCB buldular.<\/li>\n<\/ul>\n\n\n\n<p>\u0130lgili bir notta, <a href=\"https:\/\/www.mayo.edu\/research\/labs\/neurobiology-parkinsons-disease\/projects\/traumatic-brain-injury-parkinsonism#:~:text=Epidemiologic%20studies%20have%20reported%20a,increased%20risk%20of%20developing%20parkinsonism.\" target=\"_blank\" rel=\"noopener\">\u00f6nceki bir kafa travmas\u0131 da PH riskini art\u0131r\u0131r<\/a>. Hastal\u0131\u011f\u0131n kendisi gibi, ara\u015ft\u0131rmac\u0131lar da kafa yaralanmalar\u0131n\u0131n neden PH riskini art\u0131rd\u0131\u011f\u0131ndan emin de\u011filler.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tazminat Mevcut<\/h2>\n\n\n\n<p>Tehlikeli PD&#039;ye neden olan kimyasallar\u0131 yasaklayan \u00e7evre yasalar\u0131 faydal\u0131d\u0131r, ancak kurbanlara tazminat vermezler. Bunu ancak \u00e7evreci bir davac\u0131 yapabilir. Bir ki\u015fisel yaralanma durumunda tazminat genellikle kaybedilen \u00fccretler, t\u0131bbi faturalar ve cepten \u00e7\u0131kan di\u011fer ekonomik kay\u0131plarla ba\u015flar. Ma\u011fdurlar bu tazminata sadece sa\u011fl\u0131k faturalar\u0131n\u0131 \u00f6demek i\u00e7in de\u011fil, g\u00fcnl\u00fck faturalar\u0131n\u0131 da \u00f6demek i\u00e7in ihtiya\u00e7 duyarlar. Ma\u011fdurlar ayr\u0131ca duygusal s\u0131k\u0131nt\u0131 ve di\u011fer ekonomik olmayan kay\u0131plar i\u00e7in tazminat almay\u0131 hak ediyor. Bu para t\u0131bbi durumlar\u0131n\u0131 de\u011fi\u015ftirmiyor ama gelece\u011fi biraz daha parlak hale getiriyor. \u00d6nemli cezai zararlar da genellikle mevcuttur. Haks\u0131z fiil sahibinin (ihmalkar akt\u00f6r) bilinen bir riski kas\u0131tl\u0131 olarak g\u00f6z ard\u0131 etti\u011fine dair a\u00e7\u0131k ve ikna edici kan\u0131tlar varsa, j\u00fcri \u00fcyeleri bu zararlara h\u00fckmeder. Yaralanma ma\u011fdurlar\u0131 \u00f6nemli tazminat alma hakk\u0131na sahiptir. \u0130\u00e7in <a href=\"https:\/\/napolilaw.lemonadestand.org\/tr\/ucretsiz-vaka-degerlendirmesi\/\">\u00fccretsiz dan\u0131\u015fma<\/a> bilgili bir \u00e7evre davas\u0131 avukat\u0131 ile Napoli Shkolnik ile ileti\u015fime ge\u00e7in. Bize ne kadar erken ula\u015f\u0131rsan\u0131z, sizin i\u00e7in o kadar erken sava\u015fmaya ba\u015flar\u0131z.<\/p>","protected":false},"excerpt":{"rendered":"<p>Erken te\u015fhise ek olarak, yeni bir teknik, doktorlar\u0131n erken evre Parkinson Hastal\u0131\u011f\u0131 (PD) i\u00e7in daha iyi tedavi planlar\u0131 olu\u015fturmas\u0131n\u0131 sa\u011flayabilir. Alfa-sin\u00fcklein tohum amplifikasyon testi (SAA) anormallik arar\u2026<\/p>","protected":false},"author":3,"featured_media":15587,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[773],"tags":[1047,1224,1245,988,1045,1046],"class_list":["post-15586","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-environmental-litigation","tag-herbicide","tag-parkinsons-disease","tag-environmental-contamination","tag-environmental-litigation","tag-paraquat","tag-pesticide"],"acf":[],"page_builder_type":"gutenberg","gutenberg_data":[],"_links":{"self":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts\/15586","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/comments?post=15586"}],"version-history":[{"count":0,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/posts\/15586\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/media\/15587"}],"wp:attachment":[{"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/media?parent=15586"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/categories?post=15586"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/napolilaw.lemonadestand.org\/tr\/wp-json\/wp\/v2\/tags?post=15586"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}